Somatomedin-binding proteins: what role do they play in the growth process?

Eur J Pediatr. 1989 Nov;149(2):76-9. doi: 10.1007/BF01995850.


The insulin-like growth factors (IGF-I and IGF-II) circulate bound to specific proteins. Two classes of binding proteins have been relatively well characterized differing in size, immunological activity, and physiological function. This review summarizes the more recent data on IGF-binding proteins, focusing on their possible clinical implications.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carrier Proteins / pharmacology*
  • Carrier Proteins / physiology
  • Growth / drug effects*
  • Humans
  • Insulin-Like Growth Factor Binding Proteins
  • Insulin-Like Growth Factor I / biosynthesis
  • Insulin-Like Growth Factor II / biosynthesis
  • Somatomedins / pharmacology*


  • Carrier Proteins
  • Insulin-Like Growth Factor Binding Proteins
  • Somatomedins
  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor II