Size controlled hydroxyapatite and calcium carbonate particles: synthesis and their application as templates for SERS platform

B V Parakhonskiy; Yu I Svenskaya; A М Yashchenok; H A Fattah; O A Inozemtseva; F Tessarolo; R Antolini; D A Gorin

doi:10.1016/j.colsurfb.2014.03.053

Size controlled hydroxyapatite and calcium carbonate particles: synthesis and their application as templates for SERS platform

Colloids Surf B Biointerfaces. 2014 Jun 1:118:243-8. doi: 10.1016/j.colsurfb.2014.03.053. Epub 2014 Apr 18.

Authors

B V Parakhonskiy¹, Yu I Svenskaya², A М Yashchenok³, H A Fattah⁴, O A Inozemtseva⁵, F Tessarolo⁶, R Antolini⁷, D A Gorin⁸

Affiliations

¹ Department of Physics, University of Trento, 38122 Trento, Italy; A.V. Shubnikov Institute of Crystallography RAS, 119333 Moscow, Russia. Electronic address: bogdan.parakhonskiy@gmail.com.
² Department of Physics, University of Trento, 38122 Trento, Italy; Institute of Nanostructures and Biosystems, Saratov State University, 410012 Saratov, Russia.
³ Max Plank Institute of Colloids and Interfaces, Potsdam, Germany.
⁴ Faculty of Nano- and Biomedical Technologies, Saratov State University, 410012 Saratov, Russia.
⁵ Faculty of Nano- and Biomedical Technologies, Saratov State University, 410012 Saratov, Russia; Institute of Nanostructures and Biosystems, Saratov State University, 410012 Saratov, Russia.
⁶ Healthcare Research and Innovation Program (IRCS), Bruno Kessler Foundation, 38122 Trento, Italy; Department of Industrial Engineering, University of Trento, 38122 Trento, Italy.
⁷ Department of Physics, University of Trento, 38122 Trento, Italy.
⁸ Institute of Nanostructures and Biosystems, Saratov State University, 410012 Saratov, Russia; Faculty of Nano- and Biomedical Technologies, Saratov State University, 410012 Saratov, Russia. Electronic address: gorinda@mail.ru.

PMID: 24802965
DOI: 10.1016/j.colsurfb.2014.03.053

Abstract

An elegant route for hydroxyapatite (HA) particle synthesis via ionic exchange reaction is reported. Calcium carbonate particles (CaCO3) were recrystallized into HA beads in water solution with phosphate ions. The size of initial CaCO3 particles was controlled upon the synthesis by varying the amount of ethylene glycol (EG) in aqueous solution. The average size of HA beads ranged from 0.6±0.1 to 4.3±1.1μm. Silver nanoparticles were deposited on the surface of HA and CaCO3 particles via silver mirror reaction. Surface enhanced Raman scattering of silver functionalized beads was demonstrated by detecting Rhodamine B. CaCO3 and HA particles have a great potential for design of carrier which can provide diagnostic and therapeutic functions.

Keywords: Calcium carbonate; Hydroxyapatite; Particles; SERS; Silver nanoparticles; Vaterite.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Calcium Carbonate / chemistry*
Durapatite / chemistry*
Ethylene Glycol / chemistry
Microscopy, Electron, Scanning
Particle Size*
Rhodamines / chemistry
Spectrum Analysis, Raman*
X-Ray Diffraction

Substances

Rhodamines
Durapatite
Ethylene Glycol
Calcium Carbonate
rhodamine B