Age-related differences in urinary 11-dehydroxythromboxane B2 between infants, children, and adolescents: another example of developmental hemostasis?

Pediatr Blood Cancer. 2014 Nov;61(11):2074-6. doi: 10.1002/pbc.25089. Epub 2014 May 7.

Abstract

Our study was developed to ascertain reference ranges of 11-dehydrothromboxane B2 (11-dhTXB2) in the urine of healthy pediatric subjects. Urine samples were analyzed using the AspirinWorks™ assay that measures levels of 11-dehydrothromboxane B2. 128 individuals (2 months to 18 years) were identified as healthy and not receiving aspirin. When adjusted as picograms/milligrams urine creatinine, there was a negative correlation between age and level of 11-dehydrothromboxane B2 (P = 0.0001). This study confirms a negative correlation between age and level of urinary 11-dehydrothromboxane B2 and provides a set of age-specific reference ranges.

Keywords: aspirin; children; neonates; pediatric; thromboxane.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Age Factors
  • Child
  • Child, Preschool
  • Female
  • Hemostasis*
  • Humans
  • Infant
  • Male
  • Prospective Studies
  • Thromboxane B2 / analogs & derivatives*
  • Thromboxane B2 / urine

Substances

  • Thromboxane B2
  • 11-dehydro-thromboxane B2