Is the Aluminum Hypothesis dead?

J Occup Environ Med. 2014 May;56(5 Suppl):S73-9. doi: 10.1097/JOM.0000000000000063.


The Aluminum Hypothesis, the idea that aluminum exposure is involved in the etiology of Alzheimer disease, dates back to a 1965 demonstration that aluminum causes neurofibrillary tangles in the brains of rabbits. Initially the focus of intensive research, the Aluminum Hypothesis has gradually been abandoned by most researchers. Yet, despite this current indifference, the Aluminum Hypothesis continues to attract the attention of a small group of scientists and aluminum continues to be viewed with concern by some of the public. This review article discusses reasons that mainstream science has largely abandoned the Aluminum Hypothesis and explores a possible reason for some in the general public continuing to view aluminum with mistrust.

Publication types

  • Review

MeSH terms

  • Aging*
  • Aluminum / analysis
  • Aluminum / toxicity*
  • Alzheimer Disease / epidemiology*
  • Alzheimer Disease / etiology*
  • Alzheimer Disease / pathology
  • Animals
  • Brain Chemistry
  • Cooking and Eating Utensils
  • Humans
  • Neurofibrillary Tangles
  • Plaque, Amyloid / pathology
  • Reproducibility of Results


  • Aluminum