Glycine modulation of the NMDA receptor/channel complex

Trends Neurosci. 1989 Sep;12(9):349-53. doi: 10.1016/0166-2236(89)90042-8.

Abstract

One class of excitatory amino acid (EAA) receptor, the N-methyl-D-aspartate (NMDA) receptor, has excited enormous interest because of its unique pharmacological and physiological properties. Yet another property of this receptor/channel complex has recently emerged: its activation is greatly enhanced by and may even be dependent on, sub-micromolar concentrations of glycine.

Publication types

  • Review

MeSH terms

  • Amino Acids / metabolism
  • Evoked Potentials / drug effects
  • Glycine / antagonists & inhibitors
  • Glycine / pharmacology*
  • Humans
  • Ion Channels / drug effects
  • Ion Channels / physiology
  • Neurons / physiology
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Neurotransmitter / drug effects
  • Receptors, Neurotransmitter / physiology*
  • Synapses / drug effects
  • Synapses / physiology

Substances

  • Amino Acids
  • Ion Channels
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Neurotransmitter
  • Glycine