Reprint of: the ciliary marginal zone (CMZ) in development and regeneration of the vertebrate eye

Andy J Fischer; Jennifer L Bosse; Heithem M El-Hodiri

doi:10.1016/j.exer.2014.04.019

Reprint of: the ciliary marginal zone (CMZ) in development and regeneration of the vertebrate eye

Exp Eye Res. 2014 Jun:123:115-20. doi: 10.1016/j.exer.2014.04.019. Epub 2014 May 6.

Authors

Andy J Fischer¹, Jennifer L Bosse², Heithem M El-Hodiri³

Affiliations

¹ Department of Neuroscience, The Ohio State University, USA; Graduate Program in Molecular, Cellular, and Developmental Biology, The Ohio State University, USA.
² Graduate Program in Molecular, Cellular, and Developmental Biology, The Ohio State University, USA.
³ Department of Neuroscience, The Ohio State University, USA; Graduate Program in Molecular, Cellular, and Developmental Biology, The Ohio State University, USA; Department of Pediatrics, The Ohio State University, USA; Center for Molecular and Human Genetics, Nationwide Children's Research Institute, Columbus, OH, USA. Electronic address: Heithem.El-Hodiri@NationwideChildrens.org.

PMID: 24811219
DOI: 10.1016/j.exer.2014.04.019

Abstract

The ciliary marginal zone (CMZ) is a circumferential ring of cells found at the extreme periphery of the maturing and mature neural retina that consists of retinal stem and progenitor cells. It functions to add retinal neurons to the periphery of the neural retina in larval and adult fish, larval frogs, and birds. Additionally, the CMZ may contribute to regeneration of the damaged retina in frogs and fish. In mammals, cells from the ciliary epithelium can be induced to express retinal stem cell-like characteristics in culture but may not comprise a classically defined CMZ.

Keywords: ciliary marginal zone; development; regeneration; retinal progenitor cells; retinal stem cells.

Grants and funding

R01 EY015480/EY/NEI NIH HHS/United States