Bone marrow mononuclear cell therapy for acute myocardial infarction: a perspective from the cardiovascular cell therapy research network

Circ Res. 2014 May 9;114(10):1564-8. doi: 10.1161/CIRCRESAHA.114.303720.


To understand the role of bone marrow mononuclear cells in the treatment of acute myocardial infarction, this overview offers a retrospective examination of strengths and limitations of 3 contemporaneous trials with attention to critical design features and provides an analysis of the combined data set and implications for future directions in cell therapy for acute myocardial infarction.

Keywords: diagnostic imaging; myocardial infarction; population.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Bone Marrow Transplantation / methods*
  • Bone Marrow Transplantation / trends
  • Cell- and Tissue-Based Therapy / methods
  • Cell- and Tissue-Based Therapy / trends
  • Clinical Trials as Topic / methods
  • Clinical Trials as Topic / trends
  • Databases, Factual / trends
  • Humans
  • Leukocytes, Mononuclear / pathology
  • Leukocytes, Mononuclear / physiology
  • Leukocytes, Mononuclear / transplantation*
  • Myocardial Infarction / pathology*
  • Myocardial Infarction / surgery*
  • Retrospective Studies
  • Stroke Volume / physiology
  • Treatment Outcome