Dpp/BMP signaling in flies: from molecules to biology

Semin Cell Dev Biol. 2014 Aug;32:128-36. doi: 10.1016/j.semcdb.2014.04.036. Epub 2014 May 9.


Decapentaplegic (Dpp), the fly homolog of the secreted mammalian BMP2/4 signaling molecules, is involved in almost all aspects of fly development. Dpp has critical functions at all developmental stages, from patterning of the eggshell to the determination of adult intestinal stem cell identity. Here, we focus on recent findings regarding the transcriptional regulatory logic of the pathway, on a new feedback regulator, Pentagone, and on Dpp's roles in scaling and growth of the Drosophila wing.

Keywords: Activating Element; Brinker; Dally; Daughters-against-dpp; Dpp; Drosophila; Feedback regulation; Growth; Morphogen; Optomotor-blind; Patterning; Pentagone; Scaling; Silencer Element; Spalt.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Morphogenetic Proteins / genetics
  • Bone Morphogenetic Proteins / metabolism
  • Drosophila Proteins / genetics*
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / embryology
  • Drosophila melanogaster / genetics*
  • Drosophila melanogaster / growth & development
  • Extracellular Matrix Proteins / genetics
  • Extracellular Matrix Proteins / metabolism
  • Gene Expression Regulation, Developmental*
  • Models, Genetic
  • Signal Transduction / genetics*
  • Wings, Animal / embryology
  • Wings, Animal / growth & development
  • Wings, Animal / metabolism


  • Bone Morphogenetic Proteins
  • Drosophila Proteins
  • Extracellular Matrix Proteins
  • Magu protein, Drosophila
  • dpp protein, Drosophila