Guidelines of care for the management of atopic dermatitis: section 3. Management and treatment with phototherapy and systemic agents

J Am Acad Dermatol. 2014 Aug;71(2):327-49. doi: 10.1016/j.jaad.2014.03.030. Epub 2014 May 9.


Atopic dermatitis is a chronic, pruritic inflammatory dermatosis that affects up to 25% of children and 2% to 3% of adults. This guideline addresses important clinical questions that arise in atopic dermatitis management and care, providing recommendations based on the available evidence. In this third of 4 sections, treatment of atopic dermatitis with phototherapy and systemic immunomodulators, antimicrobials, and antihistamines is reviewed, including indications for use and the risk-benefit profile of each treatment option.

Keywords: atopic dermatitis; azathioprine; cyclosporin A; interferon gamma; methotrexate; mycophenolate mofetil; oral antihistamines; oral antimicrobials; oral steroids; photochemotherapy; phototherapy; systemic therapy.

Publication types

  • Practice Guideline
  • Research Support, N.I.H., Extramural

MeSH terms

  • Anti-Infective Agents / therapeutic use*
  • Azathioprine / therapeutic use
  • Cyclosporine / therapeutic use
  • Dermatitis, Atopic / drug therapy*
  • Dermatitis, Atopic / therapy
  • Histamine Antagonists / therapeutic use*
  • Humans
  • Immunologic Factors / therapeutic use*
  • Interferon-gamma / therapeutic use
  • Methotrexate / therapeutic use
  • Mycophenolic Acid / analogs & derivatives
  • Mycophenolic Acid / therapeutic use
  • Phototherapy* / adverse effects


  • Anti-Infective Agents
  • Histamine Antagonists
  • Immunologic Factors
  • Interferon-gamma
  • Cyclosporine
  • Mycophenolic Acid
  • Azathioprine
  • Methotrexate