Genetic and epigenetic underpinnings of eosinophilic esophagitis

Joseph D Sherrill; Marc E Rothenberg

doi:10.1016/j.gtc.2014.02.003

Genetic and epigenetic underpinnings of eosinophilic esophagitis

Gastroenterol Clin North Am. 2014 Jun;43(2):269-80. doi: 10.1016/j.gtc.2014.02.003. Epub 2014 Mar 24.

Authors

Joseph D Sherrill¹, Marc E Rothenberg²

Affiliations

¹ Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
² Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. Electronic address: marc.rothenberg@cchmc.org.

Abstract

Eosinophilic esophagitis (EoE) is a complex, polygenic disorder caused by genetic predisposition and environmental exposures. Because of the recent emergence of EoE as a bona fide global health concern, a paucity of available therapeutic and diagnostic options exists. However, rapid progress has been made in an effort to rectify this lack and to improve understanding of the factors that cause EoE. This article highlights key advances in elucidating the genetic (and epigenetic) components involved in EoE.

Keywords: Eotaxin-3; Epigenetics; Genetic variant; MicroRNA; Thymic stromal lymphopoietin.

MeSH terms

Eosinophilic Esophagitis / genetics*
Epigenesis, Genetic*
Humans

Abstract

MeSH terms

Grants and funding