Genetic and epigenetic underpinnings of eosinophilic esophagitis

Gastroenterol Clin North Am. 2014 Jun;43(2):269-80. doi: 10.1016/j.gtc.2014.02.003. Epub 2014 Mar 24.


Eosinophilic esophagitis (EoE) is a complex, polygenic disorder caused by genetic predisposition and environmental exposures. Because of the recent emergence of EoE as a bona fide global health concern, a paucity of available therapeutic and diagnostic options exists. However, rapid progress has been made in an effort to rectify this lack and to improve understanding of the factors that cause EoE. This article highlights key advances in elucidating the genetic (and epigenetic) components involved in EoE.

Keywords: Eotaxin-3; Epigenetics; Genetic variant; MicroRNA; Thymic stromal lymphopoietin.

MeSH terms

  • Eosinophilic Esophagitis / genetics*
  • Epigenesis, Genetic*
  • Humans