Unraveling architecture of the pluripotent genome

Curr Opin Cell Biol. 2014 Jun;28:96-104. doi: 10.1016/j.ceb.2014.04.006. Epub 2014 Jun 2.

Abstract

Genomes are folded into sophisticated configurations that both shape, and are shaped by, a diverse range of nuclear functions. High-throughput variations of Chromosome-Conformation-Capture-based technologies now enable analysis of architecture at unprecedented resolution and scale. Here I discuss the complex structure-function relationship of the mammalian genome using the model system of embryonic stem cells, and the progression from pluripotency to terminal differentiation and back again.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Lineage
  • Chromosomes / genetics
  • Gene Expression Regulation
  • Genome*
  • Humans
  • Pluripotent Stem Cells* / cytology
  • Pluripotent Stem Cells* / metabolism
  • Transcription Factors / metabolism

Substances

  • Transcription Factors