Akt-ing up on SRPK1: oncogene or tumor suppressor?

Mol Cell. 2014 May 8;54(3):329-30. doi: 10.1016/j.molcel.2014.04.020.


In this issue of Molecular Cell, Wang et al. (2014) report that the splicing kinase SRPK1 can function as both an oncogene and a tumor suppressor by modulating the activation state of the protein kinase Akt. This is shown to be mediated by the ability of SRPK1 to bind to the Akt phosphatase PHLPP1.

Publication types

  • Comment

MeSH terms

  • Animals
  • Carcinogenesis / metabolism*
  • Female
  • Humans
  • Male
  • Nuclear Proteins / metabolism*
  • Phosphoprotein Phosphatases / metabolism*
  • Protein Processing, Post-Translational*
  • Protein-Serine-Threonine Kinases / metabolism*


  • Nuclear Proteins
  • Srpk1 protein, mouse
  • Protein-Serine-Threonine Kinases
  • PHLPP1 protein, mouse
  • Phosphoprotein Phosphatases