Pressing mitochondrial genetics forward

Yu-Chan Chen; Jared Rutter

doi:10.1016/j.celrep.2014.04.028

Pressing mitochondrial genetics forward

Cell Rep. 2014 May 8;7(3):599-600. doi: 10.1016/j.celrep.2014.04.028.

Authors

Yu-Chan Chen¹, Jared Rutter²

Affiliations

¹ Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
² Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. Electronic address: rutter@biochem.utah.edu.

PMID: 24813868
DOI: 10.1016/j.celrep.2014.04.028

Abstract

Mitochondria are crucial for many cellular functions. In this issue of Cell Reports, studies from Lanning et al. and Wolf and Mootha describe RNAi approaches to screening the mitochondrial proteome. Unexpectedly, they uncover key roles for two poorly characterized mitochondrial proteins: AK4 and FASTKD4. These studies provide examples of the power of forward genetic screens, even when screening a subset of genes, in deciphering functions of previously mysterious mitochondrial proteins.

Publication types

Comment

MeSH terms

Adenosine Triphosphate / metabolism*
Adenylate Kinase / metabolism*
Energy Metabolism*
Humans
Mitochondria / enzymology*
RNA Interference*

Substances

Adenosine Triphosphate
Adenylate Kinase