Opsoclonus-myoclonus syndrome and limbic encephalitis associated with GABAB receptor antibodies in CSF

Alicia DeFelipe-Mimbrera; Jaime Masjuan; Íñigo Corral; Luisa Maria Villar; Francesc Graus; Nuria García-Barragán

doi:10.1016/j.jneuroim.2014.04.009

Opsoclonus-myoclonus syndrome and limbic encephalitis associated with GABAB receptor antibodies in CSF

J Neuroimmunol. 2014 Jul 15;272(1-2):91-3. doi: 10.1016/j.jneuroim.2014.04.009. Epub 2014 Apr 26.

Authors

Alicia DeFelipe-Mimbrera¹, Jaime Masjuan², Íñigo Corral², Luisa Maria Villar³, Francesc Graus⁴, Nuria García-Barragán²

Affiliations

¹ Department of Neurology, IRYCIS (Health Research Institute), Madrid, Spain. Electronic address: aldefelipe@gmail.com.
² Department of Neurology, IRYCIS (Health Research Institute), Madrid, Spain.
³ Immunology Hospital Universitario Ramón y Cajal, IRYCIS (Health Research Institute), Madrid, Spain.
⁴ Department of Neurology, Hospital Clínic, Universitat de Barcelona, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

PMID: 24814391
DOI: 10.1016/j.jneuroim.2014.04.009

Abstract

We report a case of a woman who had two consecutive autoimmune neurological disorders, including an opsoclonus-myoclonus syndrome (OMS) and limbic encephalitis (LE), with positive titers of GABAB receptor antibodies. The patient never developed seizures or had an underlying tumor after 4 years of follow-up.

Keywords: Autoimmune diseases; Encephalitis; GABA(B) receptor antibodies; Opsoclonus–myoclonus.

MeSH terms

Adult
Antibodies / cerebrospinal fluid*
Female
Humans
Limbic Encephalitis / cerebrospinal fluid*
Magnetic Resonance Imaging
Opsoclonus-Myoclonus Syndrome / cerebrospinal fluid*
Receptors, GABA-B / immunology*

Substances

Antibodies
Receptors, GABA-B