Irisin in response to acute and chronic whole-body vibration exercise in humans

Metabolism. 2014 Jul;63(7):918-21. doi: 10.1016/j.metabol.2014.04.001. Epub 2014 Apr 5.


Objective: Irisin is a recently identified myokine, suggested to mediate the beneficial effects of exercise by inducing browning of white adipocytes and thus increasing energy expenditure. In humans, the regulation of irisin by exercise is not completely understood. We investigated the effect of acute and chronic whole-body vibration exercise, a moderate-intensity exercise that resembles shivering, on circulating irisin levels in young healthy subjects.

Materials/methods: Healthy untrained females participated in a 6-week program of whole-body vibration exercise training. Blood was drawn before and immediately after an acute bout of exercise at baseline (week 0) and after 6 weeks of training.

Results: The resting irisin levels were not different at baseline (week 0) and after 6 weeks of training. At both 0 and 6 weeks of training, an acute bout of vibration exercise significantly elevated circulating irisin levels by 9.5% and 18.1%, respectively (p=0.05 for the percent change of irisin levels).

Conclusions: Acute bouts of whole-body vibration exercise are effective in increasing circulating irisin levels but chronic training does not change levels of baseline irisin levels in humans.

Keywords: FNDC5; Irisin; Myokine; Whole body vibration exercise.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Enzyme-Linked Immunosorbent Assay
  • Exercise*
  • Female
  • Fibronectins / blood*
  • Fibronectins / metabolism
  • Humans
  • Isometric Contraction
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / physiology*
  • Shivering
  • Time Factors
  • Up-Regulation*
  • Vibration*
  • Young Adult


  • FNDC5 protein, human
  • Fibronectins