Comparison between intravenous and intra-articular regimens of tranexamic acid in reducing blood loss during total knee arthroplasty

J Arthroplasty. 2014 Aug;29(8):1525-7. doi: 10.1016/j.arth.2014.03.039. Epub 2014 Apr 5.


Tranexamic acid is an antifibrinolytic drug used widely to prevent bleeding. Its use in reducing bleeding during total knee arthroplasty surgery is well proven but there is no final consensus regarding the regimen. The purpose of our study was to compare the effectiveness of intravenous and intra-articular regimen of tranexamic acid during the total knee arthroplasty surgery. A total of 40 patients were received three doses of intravenous tranexamic acid during total knee arthroplasty surgery. Intra-articular tranexamic acid was used in 40 patients during the surgery. We concluded that intra-articular tranexamic acid is equally effective as three dose intravenous regimen in reducing blood loss during total knee arthroplasty surgery.

Keywords: antifibrinolytic; blood loss; total knee arthroplasty; tranexamic acid.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Antifibrinolytic Agents / administration & dosage*
  • Arthroplasty, Replacement, Knee / adverse effects*
  • Blood Loss, Surgical / prevention & control*
  • Blood Transfusion
  • Female
  • Hemoglobins / metabolism
  • Humans
  • Injections, Intra-Articular
  • Injections, Intravenous
  • Male
  • Middle Aged
  • Postoperative Hemorrhage / prevention & control*
  • Tranexamic Acid / administration & dosage*


  • Antifibrinolytic Agents
  • Hemoglobins
  • Tranexamic Acid