Anti-Müllerian hormone in reproductive age women with systemic lupus erythematosus

Reumatol Clin. Mar-Apr 2015;11(2):78-82. doi: 10.1016/j.reuma.2014.03.009. Epub 2014 May 10.
[Article in En, Spanish]

Abstract

Systemic lupus erythematosus (SLE) is an inflammatory autoimmune systemic and chronic disease. Fertility in SLE patients is considered normal; factors that have been associated in these patients with ovarian failure are: disease activity, autoantibodies, and the use of cytotoxic agents. The anti-Müllerian hormone (AMH) is a marker that helps to determine the follicular reserve.

Objective: Determinate the objective was to determine AMH levels in women of reproductive age with SLE.

Material and methods: We included 65 women with SLE classified according to the 1997 ACR criteria, 18- to 40-years old. We obtained demographic, clinical, obstetric, and gynecological characteristics as well as serum levels of AMH. We performed a bivariate analysis among patients with low ovarian reserve and those with normal ovarian reserve. We also performed a correlation analysis between activity and damage index and between the cumulative cyclophosphamide dose and AMH levels.

Results: We found a median of serum AMH in SLE patients of .61 ng/mL. The prevalence of low ovarian reserve in our study was 3.07%. We found a median MEX-SLEDAI score of 1 point and the median SLICC score was 2 points. Twenty-five patients (38.4%) had used cyclophosphamide and their cumulative average dose was 7.5 grams.

Conclusions: We found a median of AMH of .61 ng/mL in our population. The prevalence of low ovarian reserve in SLE patients was 3.07%. We did not find a correlation between AMH levels, the use of cyclophosphamide, and disease activity.

Keywords: Anti-müllerian hormone; Ciclofosfamida; Cyclophosphamide; Hispanic americans; Hormona anti-mülleriana; Latinoamericanos; Lupus eritematoso sistémico; Systemic lupus erythematosus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anti-Mullerian Hormone / blood*
  • Biomarkers / blood
  • Cross-Sectional Studies
  • Female
  • Humans
  • Lupus Erythematosus, Systemic / blood*
  • Lupus Erythematosus, Systemic / physiopathology
  • Ovarian Reserve*
  • Young Adult

Substances

  • Biomarkers
  • Anti-Mullerian Hormone