Alcoholic liver disease: a synopsis of the Charles Lieber's Memorial Symposia 2009-2012

Alcohol Alcohol. Jul-Aug 2014;49(4):373-80. doi: 10.1093/alcalc/agu021. Epub 2014 May 9.

Abstract

This paper is based upon the 'Charles Lieber Satellite Symposia' organized by Manuela G. Neuman at each of the 2009-2012 Research Society on Alcoholism (RSA) Annual Meetings. The presentations represent a broad spectrum dealing with alcoholic liver disease (ALD). In addition, a literature search (2008-2013) in the discussed area was performed in order to obtain updated data. The presentations are focused on genetic polymorphisms of ethanol metabolizing enzymes and the role of cytochrome P4502E1 (CYP2E1) in ALD. In addition, alcohol-mediated hepatocarcinogenesis, immune response to alcohol and fibrogenesis in alcoholic hepatitis as well as its co-morbidities with chronic viral hepatitis infections in the presence or absence of human deficiency virus are discussed. Finally, emphasis was led on alcohol and drug interactions as well as liver transplantation for end-stage ALD.

Publication types

  • Congress
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiretroviral Therapy, Highly Active / adverse effects
  • Cytochrome P-450 CYP2E1 Inducers / pharmacokinetics
  • Cytochrome P-450 CYP2E1 Inducers / pharmacology
  • Drug Interactions
  • Ethanol / pharmacokinetics*
  • HIV Infections / complications
  • HIV Infections / drug therapy
  • Hepatitis C, Chronic / complications
  • Hepatitis C, Chronic / metabolism
  • Histamine H2 Antagonists / adverse effects
  • Humans
  • Liver Diseases, Alcoholic / complications
  • Liver Diseases, Alcoholic / enzymology*
  • Liver Diseases, Alcoholic / genetics
  • Liver Transplantation / mortality

Substances

  • Cytochrome P-450 CYP2E1 Inducers
  • Histamine H2 Antagonists
  • Ethanol