Structure of constituents isolated from the flower buds of Cananga odorata and their inhibitory effects on aldose reductase

Takahiro Matsumoto; Seikou Nakamura; Katsuyoshi Fujimoto; Tomoe Ohta; Keiko Ogawa; Masayuki Yoshikawa; Hisashi Matsuda

doi:10.1007/s11418-014-0843-y

Structure of constituents isolated from the flower buds of Cananga odorata and their inhibitory effects on aldose reductase

J Nat Med. 2014 Oct;68(4):709-16. doi: 10.1007/s11418-014-0843-y. Epub 2014 May 11.

Authors

Takahiro Matsumoto¹, Seikou Nakamura, Katsuyoshi Fujimoto, Tomoe Ohta, Keiko Ogawa, Masayuki Yoshikawa, Hisashi Matsuda

Affiliation

¹ Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.

PMID: 24816646
DOI: 10.1007/s11418-014-0843-y

Abstract

Three new terpenoid derivatives, canangaterpenes IV-VI, were isolated from the flower buds of Cananga odorata, cultivated in Thailand, together with eight known flavonoids. The chemical structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of the isolated compounds on aldose reductase were also investigated. Several terpenoid derivatives and flavonoids were shown to inhibit aldose reductase.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldehyde Reductase / antagonists & inhibitors*
Cananga / chemistry*
Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / isolation & purification
Enzyme Inhibitors / pharmacology*
Flavonoids / chemistry
Flavonoids / isolation & purification
Flavonoids / pharmacology
Flowers / chemistry
Plant Extracts / chemistry
Terpenes / chemistry*
Terpenes / isolation & purification
Terpenes / pharmacology*

Substances

Enzyme Inhibitors
Flavonoids
Plant Extracts
Terpenes
Aldehyde Reductase