Role of PET and SPECT in the study of amyotrophic lateral sclerosis

doi:10.1155/2014/237437

Review

. 2014:2014:237437.

doi: 10.1155/2014/237437. Epub 2014 Apr 10.

Role of PET and SPECT in the study of amyotrophic lateral sclerosis

Angelina Cistaro¹, Vincenzo Cuccurullo², Natale Quartuccio³, Marco Pagani⁴, Maria Consuelo Valentini⁵, Luigi Mansi²

Affiliations

¹ Positron Emission Tomography Centre IRMET S.p.A., Euromedic Inc., V. O. Vigliani 89/A, 10136 Turin, Italy ; PET Pediatric AIMN InterGroup, V. O. Vigliani 89/A, 10136 Turin, Italy ; Institute of Cognitive Sciences and Technologies, National Research Council, Piazzale Aldo Moro 7, 00185 Rome, Italy.
² Nuclear Medicine Unit, Department of Clinical and Experimental Internistic "F. Magrassi, A. Lanzara", Seconda Università di Napoli, Vico Luigi de Crecchio 16, 80138 Naples, Italy.
³ Nuclear Medicine Unit, Department of Biomedical Sciences and of Morphological and Functional Images, University of Messina, Via Consolare Valeria 1, 98125 Messina, Italy.
⁴ Department of Nuclear Medicine, Karolinska University Hospital, Solnavägen 1, Solna, 171 77 Stockholm, Sweden ; Institute of Cognitive Sciences and Technologies, National Research Council, Piazzale Aldo Moro 7, 00185 Rome, Italy.
⁵ Department of Neuroradiology, San Giovanni Battista-OIRM-S.Anna-CTO Hospital, Via Cherasco 15, 10126 Turin, Italy.

PMID: 24818133
PMCID: PMC4004117
DOI: 10.1155/2014/237437

Review

Role of PET and SPECT in the study of amyotrophic lateral sclerosis

Angelina Cistaro et al. Biomed Res Int. 2014.

. 2014:2014:237437.

doi: 10.1155/2014/237437. Epub 2014 Apr 10.

Authors

Angelina Cistaro¹, Vincenzo Cuccurullo², Natale Quartuccio³, Marco Pagani⁴, Maria Consuelo Valentini⁵, Luigi Mansi²

Affiliations

¹ Positron Emission Tomography Centre IRMET S.p.A., Euromedic Inc., V. O. Vigliani 89/A, 10136 Turin, Italy ; PET Pediatric AIMN InterGroup, V. O. Vigliani 89/A, 10136 Turin, Italy ; Institute of Cognitive Sciences and Technologies, National Research Council, Piazzale Aldo Moro 7, 00185 Rome, Italy.
² Nuclear Medicine Unit, Department of Clinical and Experimental Internistic "F. Magrassi, A. Lanzara", Seconda Università di Napoli, Vico Luigi de Crecchio 16, 80138 Naples, Italy.
³ Nuclear Medicine Unit, Department of Biomedical Sciences and of Morphological and Functional Images, University of Messina, Via Consolare Valeria 1, 98125 Messina, Italy.
⁴ Department of Nuclear Medicine, Karolinska University Hospital, Solnavägen 1, Solna, 171 77 Stockholm, Sweden ; Institute of Cognitive Sciences and Technologies, National Research Council, Piazzale Aldo Moro 7, 00185 Rome, Italy.
⁵ Department of Neuroradiology, San Giovanni Battista-OIRM-S.Anna-CTO Hospital, Via Cherasco 15, 10126 Turin, Italy.

PMID: 24818133
PMCID: PMC4004117
DOI: 10.1155/2014/237437

Abstract

Amyotrophic lateral sclerosis has been defined as a "heterogeneous group of neurodegenerative syndromes characterized by progressive muscle paralysis caused by the degeneration of motor neurons allocated in primary motor cortex, brainstem, and spinal cord." A comprehensive diagnostic workup for ALS usually includes several electrodiagnostic, clinical laboratory and genetic tests. Neuroimaging exams, such as computed tomography, magnetic resonance imaging and spinal cord myelogram, may also be required. Nuclear medicine, with PET and SPECT, may also play a role in the evaluation of patients with ALS, and provide additional information to the clinicians. This paper aims to offer to the reader a comprehensive review of the different radiotracers for the assessment of the metabolism of glucose (FDG), the measurement of cerebral blood flow (CBF), or the evaluation of neurotransmitters, astrocytes, and microglia by means of newer and not yet clinically diffuse radiopharmaceuticals.

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References

1. Cannon WB. Organization for physiological homeostasis. Physiological Reviews. 1929;9:399–431.
1. Ereshefsky M. Defining “health” and “ disease”. Studies in History and Philosophy of Science C :Studies in History and Philosophy of Biological and Biomedical Sciences. 2009;40(3):221–227. - PubMed
1. Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature. 2009;461(7267):1071–1078. - PMC - PubMed
1. Mansi L. Ich bin ein Molekularmediziner (how much CT and nuclear medicine in molecular CT?) European Journal of Nuclear Medicine and Molecular Imaging. 2009;36(3):531–532. - PubMed
1. Cascini GL, Cuccurullo V, Tamburrini O, Rotondo A, Mansi L. Peptide imaging with somatostatin analogues: more than cancer probes. Current Radiopharmaceuticals. 2013;6:36–40. - PubMed

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[1] Cannon WB. Organization for physiological homeostasis. Physiological Reviews. 1929;9:399–431.

[2] Cannon WB. Organization for physiological homeostasis. Physiological Reviews. 1929;9:399–431.

[3] Ereshefsky M. Defining “health” and “ disease”. Studies in History and Philosophy of Science C :Studies in History and Philosophy of Biological and Biomedical Sciences. 2009;40(3):221–227. - PubMed

[4] Ereshefsky M. Defining “health” and “ disease”. Studies in History and Philosophy of Science C :Studies in History and Philosophy of Biological and Biomedical Sciences. 2009;40(3):221–227. - PubMed

[5] Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature. 2009;461(7267):1071–1078. - PMC - PubMed

[6] Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature. 2009;461(7267):1071–1078. - PMC - PubMed

[7] Mansi L. Ich bin ein Molekularmediziner (how much CT and nuclear medicine in molecular CT?) European Journal of Nuclear Medicine and Molecular Imaging. 2009;36(3):531–532. - PubMed

[8] Mansi L. Ich bin ein Molekularmediziner (how much CT and nuclear medicine in molecular CT?) European Journal of Nuclear Medicine and Molecular Imaging. 2009;36(3):531–532. - PubMed

[9] Cascini GL, Cuccurullo V, Tamburrini O, Rotondo A, Mansi L. Peptide imaging with somatostatin analogues: more than cancer probes. Current Radiopharmaceuticals. 2013;6:36–40. - PubMed

[10] Cascini GL, Cuccurullo V, Tamburrini O, Rotondo A, Mansi L. Peptide imaging with somatostatin analogues: more than cancer probes. Current Radiopharmaceuticals. 2013;6:36–40. - PubMed

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Role of PET and SPECT in the study of amyotrophic lateral sclerosis

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