Atherosclerosis, some serum inflammatory markers in psoriasis

G Ital Dermatol Venereol. 2014 Apr;149(2):167-75.


Aim: Psoriasis is an autoimmune inflammatory disease which is associated with increased inflammatory markers and atherosclerosis. We wanted to investigate whether there is a relationship between some inflammatory markers and subclinical atherosclerosis markers.

Methods: We studied 60 psoriasis patients and 50 healthy controls. Demographic, biochemical parameters, C3, C4, d-dimer, CRP, fibrinogen and YKL-40 (human cartilage glycoprotein-39) levels were measured. After measuring carotid intima-media thickness (cIMT) and aortic elasticity parameters such as aortic strain, (beta) stiffness index and compliance, statistical comparisons were done.

Results: Patients with psoriasis had significantly higher diastolic blood pressure, CRP, fibrinogen, C3, uric acid levels, β-stiffness index, and cIMT values than the control group. cIMT was correlated with CRP, YKL-40 and psoriasis area and severity index (PASI) score (r=0.219, P=0.038; r=0.225, P=0.033 and r=0.275, P=0.034). Aortic strain (%), aortic compliance and aortic stiffness index were correlated with C3 (r=-0.349, r=-0.526 and r=0.235) and fibrinogen (r=-0.354, r=-0.275 and r=0.289), all P values <0.05, but not with PASI score. The presence of psoriasis was related to aortic strain (β±SE: -2.055±0.861, P=0.019) and β-stiffness index (β±SE: 2.934±1.143, P=0.012).

Conclusion: Serum C3, CRP, fibrinogen and YKL-40 levels are elevated as well as increased cIMT and impaired aortic elasticity in psoriasis. CRP, YKL-40 and PASI score are correlated with cIMT. Increased serum C3 and fibrinogen levels correlate negatively with aortic strain and aortic compliance, and correlate positively with the β-stiffness index.

MeSH terms

  • Adipokines / analysis
  • Adolescent
  • Adult
  • Aged
  • Aorta / physiopathology
  • Atherosclerosis / blood*
  • Atherosclerosis / epidemiology
  • Atherosclerosis / physiopathology
  • Biomarkers
  • Blood Cell Count
  • C-Reactive Protein / analysis
  • Carotid Intima-Media Thickness
  • Case-Control Studies
  • Chitinase-3-Like Protein 1
  • Comorbidity
  • Complement C3 / analysis
  • Complement C4 / analysis
  • Diabetes Mellitus / epidemiology
  • Dyslipidemias / epidemiology
  • Female
  • Fibrin Fibrinogen Degradation Products / analysis
  • Fibrinogen / analysis
  • Humans
  • Hypertension / drug therapy
  • Hypertension / epidemiology
  • Inflammation / blood*
  • Inflammation / epidemiology
  • Lectins / analysis
  • Male
  • Middle Aged
  • Psoriasis / blood*
  • Psoriasis / epidemiology
  • Smoking / epidemiology
  • Vascular Resistance
  • Young Adult


  • Adipokines
  • Biomarkers
  • CHI3L1 protein, human
  • Chitinase-3-Like Protein 1
  • Complement C3
  • Complement C4
  • Fibrin Fibrinogen Degradation Products
  • Lectins
  • fibrin fragment D
  • Fibrinogen
  • C-Reactive Protein