This study reports helminth infection patterns of the lizard Tropidurus hispidus from an area of semiarid caatinga in northeastern Brazil (Ceará state). The lizard population was parasitized by 8 helminth species, and the species composition of the component community resembles that found for other Neotropical lizards. The prevalence of parasites was higher for males compared with females, whereas no relation was found between intensity of infection of 2 parasites (Parapharyngodon alvarengai and Physaloptera lutzi) and the lizards body size. For reproductive females, parasite infection intensity was negatively correlated to reproductive investment.