Extended Spectrum Beta-lactamases: Definition, Classification and Epidemiology

Curr Issues Mol Biol. 2015:17:11-21. Epub 2014 May 12.

Abstract

Extended spectrum beta-lactamases (ESBLs) are defined as enzymes produced by certain bacteria that are able to hydrolyze extended spectrum cephalosporin. They are therefore effective against beta-lactam antibiotics such as ceftazidime, ceftriaxone, cefotaxime and oxyimino-monobactam. The objective of the current review is to provide a better understanding of ESBL and the epidemiology of ESBL producing organisms which are among those responsible for antibiotic resistant strains. Globally, ESBLs are considered to be problematic, particularly in hospitalized patients. There is an increasing frequency of ESBL in different parts of the world. The high risk patients are those contaminated with ESBL producer strains as it renders treatment to be ineffective in these patients. Thus, there an immediate needs to identify EBSL and formulate strategic policy initiatives to reduce their prevalence.

Publication types

  • Review

MeSH terms

  • Bacteria / drug effects
  • Bacteria / enzymology
  • Bacteria / genetics
  • Bacterial Infections / drug therapy
  • Bacterial Infections / epidemiology
  • Bacterial Infections / microbiology
  • Global Health
  • Humans
  • Risk Factors
  • beta-Lactam Resistance*
  • beta-Lactamases / chemistry
  • beta-Lactamases / classification
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism*
  • beta-Lactams / pharmacology*
  • beta-Lactams / therapeutic use

Substances

  • beta-Lactams
  • beta-Lactamases