Expression of profibrotic growth factors and their receptors by mouse lung macrophages and fibroblasts under conditions of acute viral inflammation in influenza A/H5N1 virus

A G Anikina; V A Shkurupii; O V Potapova; A V Kovner; A M Shestopalov

doi:10.1007/s10517-014-2463-7

Expression of profibrotic growth factors and their receptors by mouse lung macrophages and fibroblasts under conditions of acute viral inflammation in influenza A/H5N1 virus

Bull Exp Biol Med. 2014 Apr;156(6):833-7. doi: 10.1007/s10517-014-2463-7. Epub 2014 May 3.

Authors

A G Anikina¹, V A Shkurupii, O V Potapova, A V Kovner, A M Shestopalov

Affiliation

¹ Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.

PMID: 24824710
DOI: 10.1007/s10517-014-2463-7

Abstract

Morphological signs of early interstitial fibrosis, developing under conditions of acute viral inflammation (postinfection days 1-14), were observed in C57Bl/6 mice infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus. The development of fibrosis was confirmed by an increase in the number of lung cells expressing TNF-α. These changes were recorded in the presence of a many-fold increase in the counts of macrophages and fibroblasts expressing FGF, EGF, and their receptors.

MeSH terms

Animals
Epidermal Growth Factor / metabolism
ErbB Receptors / metabolism
Fibroblast Growth Factors / metabolism
Fibroblasts / metabolism*
Histological Techniques
Immunohistochemistry
Influenza A Virus, H5N1 Subtype*
Macrophages, Alveolar / metabolism*
Male
Mice
Mice, Inbred C57BL
Orthomyxoviridae Infections / complications
Orthomyxoviridae Infections / metabolism*
Pulmonary Fibrosis / etiology
Pulmonary Fibrosis / metabolism*
Receptors, Fibroblast Growth Factor / metabolism

Substances

Receptors, Fibroblast Growth Factor
Fibroblast Growth Factors
Epidermal Growth Factor
ErbB Receptors