Expression of profibrotic growth factors and their receptors by mouse lung macrophages and fibroblasts under conditions of acute viral inflammation in influenza A/H5N1 virus

Bull Exp Biol Med. 2014 Apr;156(6):833-7. doi: 10.1007/s10517-014-2463-7. Epub 2014 May 3.


Morphological signs of early interstitial fibrosis, developing under conditions of acute viral inflammation (postinfection days 1-14), were observed in C57Bl/6 mice infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus. The development of fibrosis was confirmed by an increase in the number of lung cells expressing TNF-α. These changes were recorded in the presence of a many-fold increase in the counts of macrophages and fibroblasts expressing FGF, EGF, and their receptors.

MeSH terms

  • Animals
  • Epidermal Growth Factor / metabolism
  • ErbB Receptors / metabolism
  • Fibroblast Growth Factors / metabolism
  • Fibroblasts / metabolism*
  • Histological Techniques
  • Immunohistochemistry
  • Influenza A Virus, H5N1 Subtype*
  • Macrophages, Alveolar / metabolism*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Orthomyxoviridae Infections / complications
  • Orthomyxoviridae Infections / metabolism*
  • Pulmonary Fibrosis / etiology
  • Pulmonary Fibrosis / metabolism*
  • Receptors, Fibroblast Growth Factor / metabolism


  • Receptors, Fibroblast Growth Factor
  • Fibroblast Growth Factors
  • Epidermal Growth Factor
  • ErbB Receptors