Detection of antigen specific circulating immune complexes in Indian kala-azar

Ann Trop Med Parasitol. 1989 Oct;83(5):521-5. doi: 10.1080/00034983.1989.11812381.


The sera of active and treated cases of kala-azar were tested for circulating immune complexes (CIC) by antigen-specific enzyme linked immunosorbent assay (ELISA). All (100%) of proved cases had elevated CIC; 64.3% of clinically diagnosed cases and 58.8% of treated cases were also positive for CIC. A fall in the level of CIC was observed after treatment. Detection of antigen-specific CIC may be useful in monitoring the therapeutic effect and recovery.

MeSH terms

  • Animals
  • Antibodies, Protozoan / analysis
  • Antigen-Antibody Complex / analysis*
  • Antigens, Protozoan / immunology*
  • Enzyme-Linked Immunosorbent Assay
  • Epitopes / immunology
  • Humans
  • Immunoglobulins / analysis
  • India
  • Leishmania donovani / immunology*
  • Leishmaniasis, Visceral / immunology*


  • Antibodies, Protozoan
  • Antigen-Antibody Complex
  • Antigens, Protozoan
  • Epitopes
  • Immunoglobulins