The CD2-LFA-3 and LFA-1-ICAM pathways: relevance to T-cell recognition

Immunol Today. 1989 Dec;10(12):417-22. doi: 10.1016/0167-5699(89)90039-X.


No process is more central to T-lymphocyte function than cell-cell adhesion, yet it is only recently that interest in lymphocyte adhesion has burgeoned. Neglect of adhesion is particularly surprising since immunologists are surrounded by a veritable sea of adhesive interactions of lymphocytic cells: transformed lymphocytes grow in aggregates, stimulated lymphocytes aggregate and T cells conjugate with their targets. In retrospect, it is obvious that all lymphocyte adhesion (both antigen-specific and seemingly non-specific adhesive interactions) has to be based on specific receptor-ligand interactions. In this review Malegapuru Makgoba, Martin Sanders and Stephen Shaw focus primarily on the two molecular pathways of lymphocyte adhesion that have been shown to play a critical role in facilitation of antigen-specific recognition, namely CD2 and its ligand, lymphocyte function associated antigen-3 (LFA-3), and LFA-1 and its ligand, intercellular adhesion molecule-1 (ICAM-1). A variety of excellent recent reviews have dealt with this and related aspects of T-cell adhesion. Of particular interest is the review that follows in this issue: it deals with the CD44 molecule which has also been implicated in both adhesion and activation of T cells.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antigens, Differentiation / physiology*
  • Antigens, Differentiation, T-Lymphocyte / physiology*
  • Antigens, Surface / physiology*
  • CD2 Antigens
  • CD58 Antigens
  • Cations, Divalent / metabolism
  • Cell Adhesion Molecules / physiology*
  • Cell Adhesion*
  • Cell Communication
  • Endothelium, Vascular / cytology
  • Humans
  • Immunologic Surveillance
  • Integrins / physiology*
  • Intercellular Adhesion Molecule-1
  • Lymphocyte Activation
  • Lymphocyte Function-Associated Antigen-1
  • Membrane Glycoproteins / physiology*
  • Models, Biological
  • Receptors, Antigen, T-Cell / physiology
  • Receptors, Immunologic / physiology*
  • Receptors, Leukocyte-Adhesion / physiology*
  • Signal Transduction
  • T-Lymphocytes / cytology*


  • Antigens, Differentiation
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Surface
  • CD2 Antigens
  • CD58 Antigens
  • Cations, Divalent
  • Cell Adhesion Molecules
  • Integrins
  • Lymphocyte Function-Associated Antigen-1
  • Membrane Glycoproteins
  • Receptors, Antigen, T-Cell
  • Receptors, Immunologic
  • Receptors, Leukocyte-Adhesion
  • Intercellular Adhesion Molecule-1