Hydrogen gas presents a promising therapeutic strategy for sepsis

Biomed Res Int. 2014;2014:807635. doi: 10.1155/2014/807635. Epub 2014 Apr 16.

Abstract

Sepsis is characterized by a severe inflammatory response to infection. It remains a major cause of morbidity and mortality in critically ill patients despite developments in monitoring devices, diagnostic tools, and new therapeutic options. Recently, some studies have found that molecular hydrogen is a new therapeutic gas. Our studies have found that hydrogen gas can improve the survival and organ damage in mice and rats with cecal ligation and puncture, zymosan, and lipopolysaccharide-induced sepsis. The mechanisms are associated with the regulation of oxidative stress, inflammatory response, and apoptosis, which might be through NF- κ B and Nrf2/HO-1 signaling pathway. In this paper, we summarized the progress of hydrogen treatment in sepsis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Hydrogen / therapeutic use*
  • Sepsis / drug therapy*
  • Sodium Chloride / therapeutic use

Substances

  • Sodium Chloride
  • Hydrogen