Treatment of symptoms of erythemato-telangiectatic rosacea with topical potassium azeloyl diglycinate and hydroxypropyl chitosan: Results of a sponsor-free, multicenter, open study

J Dermatolog Treat. 2015 Apr;26(2):191-2. doi: 10.3109/09546634.2014.921275. Epub 2014 May 27.

Abstract

Thirty-seven adult Caucasian patients (9 males and 28 females), with erythemato-telangiectatic rosacea accompanied by stinging and burning sensation, were treated with a cream containing 5% potassium azeloyl diglycinate and 1% hydroxypropyl chitosan. All patients were previously treated at other centers with topical azelaic acid and/or metronidazole. The cream was applied twice daily for 12 weeks. The objective of the study was the evaluation of the soothing effect of the cream: stinging and burning sensation were measured by means of a 4-point scale (0 = absent, 1 = mild, 2 = moderate, and 3 = severe). All patients were clinically evaluated every 4 weeks. Of 37 patients (81.1%), 30 were considered evaluable. Before the beginning of the study, the total score of stinging and burning sensation was 66 (mean: 2.2 points/patient); at the end of the study, it was 37 points (-29) (mean: 1.2 points/patient), with a reduction of 56.1%. No side effects were reported or observed. This study shows that the fixed combination potassium azeloyl diglycinate - hydroxypropyl chitosan is effective in reducing stinging and burning sensation in patients with erythemato-telangiectatic rosacea.

Keywords: Azelaic acid; azeloglycine; glycine; hydroxypropyl chitosan; potassium azeloyl diglycinate; rosacea.

Publication types

  • Multicenter Study

MeSH terms

  • Administration, Cutaneous
  • Adult
  • Aged
  • Chitosan / administration & dosage
  • Chitosan / analogs & derivatives*
  • Chitosan / therapeutic use
  • Dermatologic Agents / administration & dosage
  • Dermatologic Agents / therapeutic use
  • Female
  • Glycine / administration & dosage
  • Glycine / analogs & derivatives*
  • Glycine / therapeutic use
  • Humans
  • Male
  • Metronidazole / administration & dosage
  • Middle Aged
  • Rosacea / drug therapy*
  • Rosacea / pathology

Substances

  • Dermatologic Agents
  • P-3075
  • Metronidazole
  • Chitosan
  • Glycine