Endocrine side-effects of anti-cancer drugs: thyroid effects of tyrosine kinase inhibitors

Eur J Endocrinol. 2014 Sep;171(3):R91-9. doi: 10.1530/EJE-14-0198. Epub 2014 May 15.


Tyrosine kinase inhibitors (TKIs) are currently used by most oncologists. Among their side effects, thyroid dysfunctions are nowadays clearly observed. Whereas changes in thyroid function tests have been originally described with sunitinib, we now know that many TKIs can induce hypothyroidism and hyperthyroidism. In this study, the various molecules implicated in thyroid dysfunctions are analysed and the latest data on physiopathological mechanisms are approached in order to propose a strategy of thyroid monitoring of patients on TKI therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / adverse effects*
  • Endocrine System / drug effects*
  • Endocrine System / metabolism
  • Humans
  • Protein Kinase Inhibitors / adverse effects*
  • Thyroid Diseases / chemically induced*
  • Thyroid Diseases / metabolism
  • Thyroid Function Tests / methods
  • Thyroid Gland / drug effects*
  • Thyroid Gland / metabolism
  • Thyroid Hormones / metabolism


  • Antineoplastic Agents
  • Protein Kinase Inhibitors
  • Thyroid Hormones