Outcomes following placement of non-cross-linked porcine-derived acellular dermal matrix in complex ventral hernia repair

Int Surg. 2014 May-Jun;99(3):235-40. doi: 10.9738/INTSURG-D-13-00170.1.


Repair of complex ventral hernias frequently results in postoperative complications. This study assessed postoperative outcomes in a consecutive cohort of patients with ventral hernias who underwent herniorrhaphy using components separation techniques and reinforcement with non-cross-linked intact porcine-derived acellular dermal matrix (PADM) performed by a single surgeon between 2008 and 2012. Postoperative outcomes of interest included incidence of seroma, wound infection, deep-vein thrombosis, bleeding, and hernia recurrence determined via clinical examination. Of the 47 patients included in the study, 25% were classified as having Ventral Hernia Working Group grade 1 risk, 62% as grade 2, 2% as grade 3, and 11% as grade 4; 49% had undergone previous ventral hernia repair. During a mean follow-up of 31 months, 3 patients experienced hernia recurrence, and 9 experienced other postoperative complications: 4 (9%) experienced deep-vein thrombosis; 3 (6%), seroma; 2 (4%), wound infection; and 2 (4%), bleeding. The use of PADM reinforcement following components separation resulted in low rates of postoperative complications and hernia recurrence in this cohort of patients undergoing ventral hernia repair.

Keywords: Biologic tissue matrix; Components separation; Synthetic mesh; Ventral hernia repair.

MeSH terms

  • Acellular Dermis*
  • Adult
  • Aged
  • Aged, 80 and over
  • Animals
  • Cohort Studies
  • Comorbidity
  • Female
  • Hernia, Ventral / epidemiology
  • Hernia, Ventral / surgery*
  • Herniorrhaphy / methods*
  • Herniorrhaphy / statistics & numerical data
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Surgical Mesh
  • Swine
  • Treatment Outcome