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Review
. 2015 Oct;80(4):827-33.
doi: 10.1111/bcp.12423. Epub 2015 Jul 2.

Quality of Life in Children With Adverse Drug Reactions: A Narrative and Systematic Review

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Free PMC article
Review

Quality of Life in Children With Adverse Drug Reactions: A Narrative and Systematic Review

Blanca R Del Pozzo-Magaña et al. Br J Clin Pharmacol. .
Free PMC article

Abstract

Aims: Adverse drug reactions are a common problem affecting adults and children. The economic impact of the adverse drug reactions has been widely evaluated; however, studies of the impact on the quality of life of children with adverse drug reactions are scarce. The aim was to evaluate studies assessing the health-related quality of life of children with adverse drug reactions.

Methods: We conducted a systematic review that included the following electronic databases: MEDLINE, EMBASE and the Cochrane Library (including the Cochrane Database of Systematic Reviews, the Database of Abstracts of Reviews of Effects, the Cochrane Controlled Trials Register and the Health Technology Assessment Databases).

Results: Nine studies were included. Four of the studies were conducted in children with epilepsy; the rest of them involved children with chronic viral hepatitis, Crohn's disease, paediatric cancer and multiple adverse drug reactions compared with healthy children. Based on their findings, authors of all studies concluded that adverse drug reactions had a negative impact on the quality of life of children. No meta-analysis was conducted given the heterogeneous nature of the studies.

Conclusions: To date, there is no specific instrument that measures quality of life of children with adverse drug reactions, and the information available is poor and variable. In general, adverse drug reactions have a negative impact on the quality of life of affected children. For those interested in this area, more work needs to be done to improve tools that help to evaluate efficiently the health-related quality of life of children with adverse drug reactions and chronic diseases.

Keywords: adverse drug reactions; children; health-related quality of life; quality of life.

Figures

Figure 1
Figure 1
Flow diagram of the systematic review. Abbreviations are as follows: ADRs, adverse drug reactions; HRQL, health-related quality of life. *Four references were available only in abstract form. †The final number of included references was 10, comprising nine studies. One study was reported twice in consecutive years

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