Bridging the gaps between the histopathological and demographic risk factors of preterm birth in a unique Miami inner-city population

Fetal Pediatr Pathol. 2014 Aug;33(4):226-33. doi: 10.3109/15513815.2014.913749. Epub 2014 May 15.


We aim to identify the link between placental histological findings and obstetric reports to determine possible risk factors of spontaneous preterm birth (SPTB). We prospectively ascertained birth records and outcomes from all deliveries in our hospital in 1 year. Records were used to determine and stratify for either full-term or preterm [spontaneous or indicated (I)] deliveries. We analyzed for risk factor association using χ(2) tests and common odds ratio estimates (SPSS v21.0). Our cohort totaled 6088 deliveries: 236 IPTB, 43 SPTB, and 5809 term births. Largely Hispanic, we determined race, parity, prenatal care access, preeclampsia, gestational diabetes, and BMI to be highly associated with SPTB (p < 0.01). Histologically, placentas of women with SPTB were twice as likely to have chronic villitis. We found that chronic villitis is associated with SPTB. Results of this study can be used in increasing the understanding of SPTB.

Keywords: chronic villitis; obstetrics; placenta; premature; spontaneous preterm birth.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cohort Studies
  • Demography
  • Diabetes, Gestational / epidemiology
  • Female
  • Florida / epidemiology
  • Humans
  • Infant, Newborn
  • Placenta / pathology
  • Placenta Diseases / epidemiology
  • Placenta Diseases / pathology
  • Pre-Eclampsia / epidemiology
  • Pregnancy
  • Premature Birth / epidemiology
  • Premature Birth / etiology*
  • Premature Birth / pathology*
  • Prenatal Care
  • Prospective Studies
  • Risk Factors
  • Urban Population
  • Young Adult