Aim: In this study, we was tried to prepare a nano compound with a new way in functionalization as anti gastric cancer candidate.
Background: Functionalization of nanotubes is a useful route for modification of their biologic properties. (3-oxoindolin-2-ylidene) urea is a chemical compound that made of isatin and urea that can be useful in cancer study.
Patients and methods: MWNT-COOH was functionalized by this compound with one-step reaction that is a new class in modification. Product has been investigated by FT-IR, Raman and SEM. Anti cancer investigation with human gastric cells and MTT assay test for measurement of viable cell numbers were also performed.
Results: The two bands at around 2800-2900 cm(-1) which are seen in functionalized product are attributed to the CH stretching of MWNT-COOH defects.
Conclusion: Cellular results demonstrated that the functionalized nano-tube is a more toxic agent compared to other samples for cancer cells and can be used as a candidate material for chemotherapy.
Keywords: Anti cancer; Functionalization; MTT; One-pot reaction.