The Expression of CD34(+)/C-kit(+) Stem Cells in Peripheral Blood in Infants After Deep Hypothermia Circulatory Arrest

Gan Jiang; Zhiwei Xu

doi:10.1089/ther.2013.0007

The Expression of CD34(+)/C-kit(+) Stem Cells in Peripheral Blood in Infants After Deep Hypothermia Circulatory Arrest

Ther Hypothermia Temp Manag. 2013 Sep;3(3):122-5. doi: 10.1089/ther.2013.0007.

Authors

Gan Jiang¹, Zhiwei Xu

Affiliation

¹ Department of Thoracic Cardiac Surgery, Shanghai Children's Heart Center, Shanghai Jiaotong University School of Medicine , Shanghai, China .

PMID: 24834842
DOI: 10.1089/ther.2013.0007

Abstract

To investigate the effect of deep hypothermic circulatory arrest (DHCA) on the expression of a CD34(+)/C-kit(+) progenitor cell population in peripheral blood in infants. The expression of CD34(+)/C-kit(+) stem cells in peripheral blood of 10 patients after DHCA was measured before institution of cardiopulmonary bypass (CPB) (T0), at 12-24 hours (T1) and 4-5 days (T2) after cessation of CPB, respectively. The level of CD34(+)/C-kit(+) stem cells in peripheral blood was significantly higher in the DHCA group at T1 and T2 (p<0.01). Our data show that DHCA may cause the increase of CD34(+)/C-kit(+) stem cells in peripheral blood after surgery. The role of increase of CD34(+)/C-kit(+) stem cells in peripheral blood on the beneficial effects of DHCA needs to be studied.