Genome-wide association study identifies genomic regions of association for cruciate ligament rupture in Newfoundland dogs

Anim Genet. 2014 Aug;45(4):542-9. doi: 10.1111/age.12162. Epub 2014 May 16.


Cranial cruciate ligament rupture (CCLR) is the most common cause of pelvic limb lameness in dogs. To investigate the genetic basis of canine CCLR, we conducted a genome-wide association study using a canine SNP array in Newfoundland pedigree dogs with and without CCLR (n = 96). We identified three main chromosomal regions of CCLR association (on chromosomes 1, 3 and 33). Each of these regions was confirmed by Sequenom genotyping in a further cohort of Newfoundlands (n = 271). The results, particularly SNPs identified in the SORCS2 and SEMA5B genes, suggest that there may be neurological pathways involved in susceptibility to canine CCLR.

Keywords: Newfoundlands; cranial cruciate ligament rupture; population stratification.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anterior Cruciate Ligament Injuries*
  • Dog Diseases / epidemiology
  • Dog Diseases / genetics*
  • Dogs / injuries*
  • Genome-Wide Association Study / veterinary*
  • Polymorphism, Single Nucleotide*
  • Species Specificity