[Oral toxicity of targeted anticancer therapies]

Ann Dermatol Venereol. 2014 May;141(5):354-63. doi: 10.1016/j.annder.2014.03.009. Epub 2014 Apr 13.
[Article in French]

Abstract

While toxicity of targeted anticancer therapies on the oral mucosa seems relatively frequent in clinical practice, it has not been properly characterized to date, apart from aphthous-like lesions due to mTOR inhibitors. Herein, we report the main oral lesions associated with these new therapies, with a description of the most frequent but also the most characteristic clinical manifestations of these drugs, such as anti-EGFR-induced mucositis, BRAF-inhibitor-associated hyperkeratosis, benign migratory glossitis and osteonecrosis of the jaw observed with angiogenesis inhibitors, as well as lesions more specifically linked with imatinib.

Keywords: Aphthous-like lesions; Benign migratory glossitis; Glossite migratrice bénigne; Hyperkeratosis; Hyperkératose; Lésions buccales; Mucite; Mucositis; Oral lesions; Osteonecrosis of the jaw; Ostéonécrose de la mâchoire; Targeted therapies; Thérapies ciblées; Ulcérations aphtoïdes.

Publication types

  • Review

MeSH terms

  • Angiogenesis Inhibitors / adverse effects
  • Benzamides / adverse effects
  • ErbB Receptors / antagonists & inhibitors
  • Glossitis, Benign Migratory / chemically induced
  • Humans
  • Hyperpigmentation / chemically induced
  • Imatinib Mesylate
  • Indoles / adverse effects
  • Maxillary Diseases / chemically induced
  • Maxillary Diseases / pathology
  • Molecular Targeted Therapy / adverse effects*
  • Molecular Targeted Therapy / methods
  • Mouth Mucosa / drug effects
  • Mouth Mucosa / pathology
  • Osteonecrosis / chemically induced
  • Osteonecrosis / pathology
  • Piperazines / adverse effects
  • Protein Kinase Inhibitors / adverse effects
  • Proto-Oncogene Proteins B-raf / antagonists & inhibitors
  • Pyrimidines / adverse effects
  • Pyrroles / adverse effects
  • Radiation Injuries / complications
  • Radiotherapy / adverse effects
  • Stomatitis / chemically induced*
  • Stomatitis / pathology
  • Stomatitis, Aphthous / chemically induced
  • Stomatitis, Aphthous / pathology
  • Sunitinib
  • TOR Serine-Threonine Kinases / adverse effects

Substances

  • Angiogenesis Inhibitors
  • Benzamides
  • Indoles
  • Piperazines
  • Protein Kinase Inhibitors
  • Pyrimidines
  • Pyrroles
  • Imatinib Mesylate
  • TOR Serine-Threonine Kinases
  • ErbB Receptors
  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf
  • Sunitinib