The gut microbiome, probiotics, bile acids axis, and human health

Mitchell Lawrence Jones; Catherine Tomaro-Duchesneau; Satya Prakash

doi:10.1016/j.tim.2014.04.010

The gut microbiome, probiotics, bile acids axis, and human health

Trends Microbiol. 2014 Jun;22(6):306-8. doi: 10.1016/j.tim.2014.04.010. Epub 2014 May 14.

Authors

Mitchell Lawrence Jones¹, Catherine Tomaro-Duchesneau¹, Satya Prakash²

Affiliations

¹ Biomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering, Physiology and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, Quebec, H3A 2B4, Canada.
² Biomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering, Physiology and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, Quebec, H3A 2B4, Canada. Electronic address: satya.prakash@mcgill.ca.

PMID: 24836108
DOI: 10.1016/j.tim.2014.04.010

Abstract

The human gut microbiome produces potent ligands to bile acid receptors, and probiotics could act as therapeutics of bile acid dysmetabolism. A recent study in Cell Reports demonstrates that probiotic VSL#3 affects bile acid deconjugation and excretion, as well as the gut-liver FXR-FGF15 axis.

MeSH terms

Bile Acids and Salts / metabolism*
Humans
Ligands
Microbiota / drug effects*
Models, Biological
Probiotics / therapeutic use*

Substances

Bile Acids and Salts
Ligands