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Multicenter Study
. Jul-Aug 2014;21(8-9):1098-103.
doi: 10.1016/j.phymed.2014.04.004. Epub 2014 May 15.

Hyperactivity, Concentration Difficulties and Impulsiveness Improve During Seven Weeks' Treatment With Valerian Root and Lemon Balm Extracts in Primary School Children

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Multicenter Study

Hyperactivity, Concentration Difficulties and Impulsiveness Improve During Seven Weeks' Treatment With Valerian Root and Lemon Balm Extracts in Primary School Children

Jürgen Gromball et al. Phytomedicine. .
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Abstract

Background: Valerian root and lemon balm extracts have previously shown efficacy and excellent tolerability in children<12 years suffering from restlessness and insomnia. We now examined whether treatment with a fixed combination of both may also improve concentration, hyperactivity and impulsiveness.

Methods: 169 primary school children suffering from hyperactivity and concentration difficulties but not meeting ADHS criteria were treated in an observational study by 27 office based pediatricians with a recommended daily dose of 640 mg valerian root extract WS(®) 1014 and 320 mg lemon balm extract WS(®) 1303 (Sandrin(®)), and evaluated by pediatricians and parents using standardized questionnaires at baseline, weeks 2 and 7.

Results: The fraction of children having strong/very strong symptoms of poor ability to focus decreased from 75% to 14%, hyperactivity from 61% to 13%, and impulsiveness from 59% to 22%. Parent rated social behavior, sleep and symptom burden showed highly significant improvements. Only in two children mild transient adverse drug reactions were observed.

Conclusion: In primary school children with restlessness, concentration difficulties and impulsiveness treatment with WS(®) 1014 and WS(®) 1303 (Sandrin(®)) provides a viable option in addition to counseling and education.

Keywords: Concentration deficit; Hyperactivity; Melissa; Primary school children; Valerian-lemon balm-extract; Valeriana.

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