Working towards a group A streptococcal vaccine: report of a collaborative Trans-Tasman workshop

Vaccine. 2014 Jun 24;32(30):3713-20. doi: 10.1016/j.vaccine.2014.05.017. Epub 2014 May 14.


Group A Streptococcus (GAS) infections represent a major public health burden in both developing and developed countries. In Australia and New Zealand GAS associated diseases are serious problems in Indigenous populations and a major cause of health inequality. Political recognition of these inequalities is providing impetus for strategies that reduce GAS disease and the development of a GAS vaccine now has governmental support in both Australia and New Zealand. Accordingly, an expert workshop was convened in March 2013 to consider available data on GAS vaccines. M-protein based vaccines constructed from the hyper-variable N-terminal region (30-valent vaccine) or the conserved C-repeat domain (J8 vaccine) were reviewed together with vaccine candidates identified using multi high-throughput approaches. Performing a comprehensive assessment of regional GAS strain epidemiology, defining the immune correlates of protection, and the establishment of clinical trial sites were identified as critical activities for a Trans-Tasman vaccine development programme.

Keywords: Epidemiology; M protein; Rheumatic fever; Streptococcus pyogenes; Vaccine.

MeSH terms

  • Animals
  • Australia / epidemiology
  • Clinical Trials as Topic
  • Disease Models, Animal
  • Healthcare Disparities
  • Humans
  • Molecular Epidemiology
  • New Zealand / epidemiology
  • Streptococcal Infections / epidemiology
  • Streptococcal Infections / prevention & control*
  • Streptococcal Vaccines / therapeutic use*
  • Streptococcus pyogenes / pathogenicity


  • Streptococcal Vaccines