The global burden of aortic stenosis

Prog Cardiovasc Dis. May-Jun 2014;56(6):565-71. doi: 10.1016/j.pcad.2014.02.006. Epub 2014 Mar 2.


Degenerative, calcific valvular aortic stenosis (AS), caused by an active process of atherosclerosis, calcification and ossification, is the most common cause of AS in industrialized nations. The prevalence of calcific AS is age-dependent, and thus is expected to increase due to demographic aging of the global population. It is well recognized that severe AS carries a poor prognosis if left untreated. Despite this recognition, many patients are inappropriately denied surgery because of perceived risk. This article will examine the etiology, prevalence, and current trends in the treatment of degenerative AS focusing on indications for surgical aortic valve replacement.

Keywords: Aortic stenosis; Aortic valve replacement; Prevalence.

Publication types

  • Review

MeSH terms

  • Age Factors
  • Animals
  • Aortic Valve / pathology*
  • Aortic Valve / physiopathology
  • Aortic Valve / surgery
  • Aortic Valve Stenosis / diagnosis
  • Aortic Valve Stenosis / epidemiology*
  • Aortic Valve Stenosis / physiopathology
  • Aortic Valve Stenosis / surgery
  • Calcinosis / diagnosis
  • Calcinosis / epidemiology*
  • Calcinosis / physiopathology
  • Calcinosis / surgery
  • Global Health*
  • Heart Valve Prosthesis Implantation
  • Humans
  • Patient Selection
  • Prevalence
  • Risk Assessment
  • Risk Factors
  • Treatment Outcome

Supplementary concepts

  • Aortic Valve, Calcification of