Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicenter survival study

Neurobiol Aging. 2014 Oct;35(10):2420.e13-4. doi: 10.1016/j.neurobiolaging.2014.04.014. Epub 2014 Apr 19.


Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n = 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group.

Keywords: Amyotrophic lateral sclerosis; Genome-wide association study; KIFAP3; Kinesin-associated protein 3 gene.

Publication types

  • Multicenter Study

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics*
  • Aged
  • Amyotrophic Lateral Sclerosis / genetics*
  • Amyotrophic Lateral Sclerosis / mortality*
  • Cohort Studies
  • Cytoskeletal Proteins / genetics*
  • Female
  • Genetic Variation / genetics*
  • Genome-Wide Association Study*
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Survival Analysis


  • Adaptor Proteins, Signal Transducing
  • Cytoskeletal Proteins
  • KIFAP3 protein, human