Inflammation: a mechanism of depression?

Neurosci Bull. 2014 Jun;30(3):515-23. doi: 10.1007/s12264-013-1439-3. Epub 2014 May 16.


In recent decades, major depression has become more prevalent and research has shown that immune activation and cytokine production may be involved. This review is mainly focused on the contribution of inflammation to depression. We first briefly introduce the inflammatory biomarkers of depression, then discuss the sources of cytokines in the brain, and finally describe the neuroimmunological mechanisms underlying the association between inflammation and depression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Brain / metabolism
  • Brain / pathology*
  • Cytokines / metabolism
  • Depression / etiology*
  • Depression / pathology
  • Humans
  • Inflammation / complications*
  • Inflammation / pathology


  • Cytokines