The amphetamine-induced inhibition of dopamine biosynthesis in rat striatum

Eur J Pharmacol. 1976 Feb;35(2):389-92. doi: 10.1016/0014-2999(76)90242-9.

Abstract

The dopamine biosynthetic machinery of intact synaptosomes of rat striatum showed a 5-fold increase in development from 3-day-old neonates to adults, and it was fully developed between 2-3 weeks after birth. Concurring with this development was the appearance 2 weeks after birth of a regulatory mechanism(s) through which amphetamine in vivo induced an inhibition of dopamine biosynthesis. The inhibition was not appreciably reversed when haloperidol, in addition to amphetamine, was administered.

MeSH terms

  • Aging
  • Animals
  • Animals, Newborn
  • Corpus Striatum / enzymology
  • Corpus Striatum / metabolism*
  • Depression, Chemical
  • Dextroamphetamine / pharmacology*
  • Dopamine / biosynthesis*
  • Haloperidol / pharmacology
  • Rats
  • Synaptosomes / metabolism
  • Tyrosine 3-Monooxygenase / metabolism

Substances

  • Tyrosine 3-Monooxygenase
  • Haloperidol
  • Dextroamphetamine
  • Dopamine