Dietary boron modified the effects of magnesium and molybdenum on mineral metabolism in the cholecalciferol-deficient chick

Biol Trace Elem Res. 1989 Nov;22(2):201-20. doi: 10.1007/BF02916650.

Abstract

The metabolic effects of dietary boron, magnesium, and molybdenum on mineral metabolism in the cholecalciferol-deficient chick, with emphasis on growth cartilage histology, were studied. One-day-old cockerel chicks were assigned to groups in a fully-crossed, three factor, 2 x 2 x 2 design. The basal diet was based on ground corn, high-protein casein, and corn oil and contained 125 IU cholecalciferol (inadequate), 0.465 mg B, 2.500 mg Mg, and 0.420 mg Mo/kg. The treatments were the supplementation of the basal diet with B at O or 3; Mg at 300 (inadequate) or 500 (adequate); and Mo at 0 or 20 mg/kg. At d 25, B depressed mortality, alleviated the cholecalciferol-deficiency induced distortion of the marrow sprouts (MS) of the proximal tibial epiphysial plate, and elevated the numbers of osteoclasts within the MS. Adequate Mg exacerbated the cholecalciferol-deficiency induced bone lesions. Mo widened the MS markedly. In Mg-deficient chicks, B elevated plasma Ca and Mg concentrations and growth, but inhibited initiation of cartilage calcification; B had the opposite effect in Mg-adequate chicks. An interaction among B, Mg, and Mo affected plasma uric acid and glucose concentrations. B may function to modify mineral metabolism in cholecalciferol deficiency, suppressing bone anabolism in concurrent Mg deficiency and bone catabolism in concurrent Mg adequacy.

MeSH terms

  • Animals
  • Animals, Newborn / metabolism
  • Bone Marrow / anatomy & histology
  • Bone Marrow / metabolism
  • Boron / pharmacology*
  • Calcification, Physiologic / drug effects
  • Cartilage / anatomy & histology
  • Cartilage / metabolism
  • Chickens
  • Cholecalciferol / deficiency*
  • Diet
  • Magnesium / pharmacology*
  • Male
  • Minerals / metabolism*
  • Molybdenum / pharmacology*

Substances

  • Minerals
  • Cholecalciferol
  • Molybdenum
  • Magnesium
  • Boron