slanDCs in carcinoma-draining lymph nodes

Oncoimmunology. 2014 Jan 1;3(3):e28246. doi: 10.4161/onci.28246. Epub 2014 Mar 17.


Dendritic cells (DCs) are known to initiate adaptive immune responses against malignant cells. However, the role in anticancer immunosurveillance of 6-sulfo LacNAc-expressing DCs (slanDCs), a distinct population of circulating and tissue-resident pro-inflammatory DCs, is unclear. We have recently demonstrated the involvement of slanDCs in nodal immune responses against carcinoma cells.

Keywords: carcinoma; slanDCs; tumor-draining lymph nodes.