Immune checkpoints: A therapeutic target in triple negative breast cancer

Oncoimmunology. 2014 Jan 1;3(3):e28325. doi: 10.4161/onci.28325. Epub 2014 Apr 8.


Early clinical trials investigating monoclonal antibodies targeting the T-cell inhibitory receptor programmed cell death 1 (PD-1) and its ligand PD-L1 have shown efficacy in melanoma, non-small cell lung cancer and renal cell carcinoma. We recently demonstrated PD-L1 expression in 20% of triple negative breast cancers suggesting that targeting the PD-1/PD-L1 immune checkpoint may be an effective treatment modality in patients with this disease.

Keywords: PD-L1; PI3K; biomarker; immunotherapy; triple negative breast cancer.