Abstract
Acne is a chronic inflammatory human skin disease, characterized by areas of skin with seborrhoea, comedones, papules, nodules, pimples, and possibly scarring with lesions occurring on face, neck, and back. Nanotechnological approaches such as particulate (solid lipid nanoparticles and microspheres), vesicular (liposomes and niosomes), colloidal drug delivery systems (micro-emulsion and nano-emulsion), and miscellaneous systems (aerosol foams and micro-sponges) have an important place in acne therapy. These approaches have an enormous opportunity for the designing of a novel, low-dose and effective treatment systems to control acne disease. In this review, we specially focus on the different nanotechnological approaches for an effective treatment of acne.
Keywords:
Propionibacterium acnes; acne vulgaris; fullerenes; liposomes; micro-sponge.
MeSH terms
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Acne Vulgaris / metabolism
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Acne Vulgaris / microbiology
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Acne Vulgaris / pathology
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Acne Vulgaris / therapy*
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Androgen Antagonists / therapeutic use
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Androgens / biosynthesis
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Anti-Bacterial Agents / therapeutic use
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Drug Delivery Systems / methods*
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Emulsions
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Fullerenes / therapeutic use
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Humans
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Liposomes / chemistry
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Liposomes / pharmacokinetics
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Liposomes / therapeutic use*
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Microspheres
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Nanoparticles / chemistry
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Nanoparticles / therapeutic use*
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Plant Preparations / therapeutic use
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Propionibacterium acnes / drug effects
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Propionibacterium acnes / growth & development
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Propionibacterium acnes / pathogenicity
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Retinoids / therapeutic use
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Sebum / drug effects
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Skin / drug effects
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Skin / microbiology
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Skin / pathology
Substances
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Androgen Antagonists
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Androgens
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Anti-Bacterial Agents
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Emulsions
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Fullerenes
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Liposomes
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Plant Preparations
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Retinoids