Developmental gene expression provides clues to relationships between sponge and eumetazoan body plans

Nat Commun. 2014 May 20;5:3905. doi: 10.1038/ncomms4905.

Abstract

Elucidation of macroevolutionary transitions between diverse animal body plans remains a major challenge in evolutionary biology. We address the sponge-eumetazoan transition by analyzing expression of a broad range of eumetazoan developmental regulatory genes in Sycon ciliatum (Calcispongiae). Here we show that many members of surprisingly numerous Wnt and Tgfβ gene families are expressed higher or uniquely in the adult apical end and the larval posterior end. Genes involved in formation of the eumetazoan endomesoderm, such as β-catenin, Brachyury and Gata, as well as germline markers Vasa and Pl10, are expressed during formation and maintenance of choanoderm, the feeding epithelium of sponges. Similarity in developmental gene expression between sponges and eumetazoans, especially cnidarians, is consistent with Haeckel's view that body plans of sponges and cnidarians are homologous. These results provide a framework for further studies aimed at deciphering ancestral developmental regulatory networks and their modifications during animal body plans evolution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Body Patterning / genetics*
  • Cnidaria / genetics*
  • Fetal Proteins / genetics
  • GATA Transcription Factors / genetics
  • Gene Expression Regulation, Developmental / genetics*
  • Molecular Sequence Data
  • Porifera / genetics*
  • T-Box Domain Proteins / genetics
  • Transforming Growth Factor beta / genetics
  • Wnt Proteins / genetics
  • beta Catenin / genetics

Substances

  • Fetal Proteins
  • GATA Transcription Factors
  • T-Box Domain Proteins
  • Transforming Growth Factor beta
  • Wnt Proteins
  • beta Catenin
  • Brachyury protein

Associated data

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