Ethical alternatives to experiments with novel potential pandemic pathogens

doi:10.1371/journal.pmed.1001646

. 2014 May 20;11(5):e1001646.

doi: 10.1371/journal.pmed.1001646. eCollection 2014 May.

Ethical alternatives to experiments with novel potential pandemic pathogens

Marc Lipsitch¹, Alison P Galvani²

Affiliations

¹ Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America.
² Department of Epidemiology (Microbial Diseases), Yale School of Public Health, New Haven, Connecticut, United States of America; Department of Ecology and Evolutionary Biology, Yale School of Public Health, New Haven, Connecticut, United States of America.

PMID: 24844931
PMCID: PMC4028196
DOI: 10.1371/journal.pmed.1001646

Free PMC article

Ethical alternatives to experiments with novel potential pandemic pathogens

Marc Lipsitch et al. PLoS Med. 2014.

Free PMC article

. 2014 May 20;11(5):e1001646.

doi: 10.1371/journal.pmed.1001646. eCollection 2014 May.

Authors

Marc Lipsitch¹, Alison P Galvani²

Affiliations

¹ Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America.
² Department of Epidemiology (Microbial Diseases), Yale School of Public Health, New Haven, Connecticut, United States of America; Department of Ecology and Evolutionary Biology, Yale School of Public Health, New Haven, Connecticut, United States of America.

PMID: 24844931
PMCID: PMC4028196
DOI: 10.1371/journal.pmed.1001646

Abstract

Please see later in the article for the Editors' Summary

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Conflict of interest statement

ML reports consulting income or honoraria from the following sources within the past five years: Novartis, Pfizer (pharmaceutical companies); AIR Worldwide, i3 Innovus, and Outcome Sciences (risk assessment and consulting companies). None of these relationships is ongoing. He has research grants with Pfizer (active) and PATH Vaccine Solutions (pending). AG reports consulting income from Vitality (a health insurer) and AIR Worldwide (a risk assessment company). ML is a member of the Editorial Board of PLOS Medicine.

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References

1. Imai M, Watanabe T, Hatta M, Das SC, Ozawa M, et al. (2012) Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature 486: 420–428. - PMC - PubMed
1. Herfst S, Schrauwen EJ, Linster M, Chutinimitkul S, de Wit E, et al. (2012) Airborne transmission of influenza A/H5N1 virus between ferrets. Science 336: 1534–1541. - PMC - PubMed
1. Klotz LC, Sylvester EJ (2012) The unacceptable risks of a man-made pandemic. Bulletin of the Atomic Sciences. Available: http://thebulletin.org/unacceptable-risks-man-made-pandemic. Accessed 15 April 2014.
1. Webster RG, Bean WJ, Gorman OT, Chambers TM, Kawaoka Y (1992) Evolution and ecology of influenza A viruses. Microbiol Rev 56: 152–179. - PMC - PubMed
1. Fouchier RA, Garcia-Sastre A, Kawaoka Y (2013) H5N1 virus: transmission studies resume for avian flu. Nature 493: 609. - PubMed

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[1] Imai M, Watanabe T, Hatta M, Das SC, Ozawa M, et al. (2012) Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature 486: 420–428. - PMC - PubMed

[2] Imai M, Watanabe T, Hatta M, Das SC, Ozawa M, et al. (2012) Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature 486: 420–428. - PMC - PubMed

[3] Herfst S, Schrauwen EJ, Linster M, Chutinimitkul S, de Wit E, et al. (2012) Airborne transmission of influenza A/H5N1 virus between ferrets. Science 336: 1534–1541. - PMC - PubMed

[4] Herfst S, Schrauwen EJ, Linster M, Chutinimitkul S, de Wit E, et al. (2012) Airborne transmission of influenza A/H5N1 virus between ferrets. Science 336: 1534–1541. - PMC - PubMed

[5] Klotz LC, Sylvester EJ (2012) The unacceptable risks of a man-made pandemic. Bulletin of the Atomic Sciences. Available: http://thebulletin.org/unacceptable-risks-man-made-pandemic. Accessed 15 April 2014.

[6] Klotz LC, Sylvester EJ (2012) The unacceptable risks of a man-made pandemic. Bulletin of the Atomic Sciences. Available: http://thebulletin.org/unacceptable-risks-man-made-pandemic. Accessed 15 April 2014.

[7] Webster RG, Bean WJ, Gorman OT, Chambers TM, Kawaoka Y (1992) Evolution and ecology of influenza A viruses. Microbiol Rev 56: 152–179. - PMC - PubMed

[8] Webster RG, Bean WJ, Gorman OT, Chambers TM, Kawaoka Y (1992) Evolution and ecology of influenza A viruses. Microbiol Rev 56: 152–179. - PMC - PubMed

[9] Fouchier RA, Garcia-Sastre A, Kawaoka Y (2013) H5N1 virus: transmission studies resume for avian flu. Nature 493: 609. - PubMed

[10] Fouchier RA, Garcia-Sastre A, Kawaoka Y (2013) H5N1 virus: transmission studies resume for avian flu. Nature 493: 609. - PubMed

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Ethical alternatives to experiments with novel potential pandemic pathogens

Affiliations

Ethical alternatives to experiments with novel potential pandemic pathogens

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